Modeling transcriptional feedback loops: The role of Gro/TLE1 in Hes1 oscillations
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چکیده
By Samuel Bernard, Branka Čajavec, Laurent Pujo-Menjouet, Michael C. Mackey3∗ and Hanspeter Herzel Institute for Theoretical Biology, Humboldt University, Invalidenstr. 43, 10115 Berlin, Germany., Vanderbilt University Department of Mathematics , 1326 Stevenson Center, Nashville, TN 37240, USA., Departments of Physiology, Physics & Mathematics and Centre for Nonlinear Dynamics, McGill University, 3655 Promenade Sir William Osler, Montreal, Qc, Canada, H3G 1Y6. ∗Corresponding author, M.C. Mackey. Tel: (514) 398 4336, Fax: (514) 398 7452. [email protected]
منابع مشابه
Modelling transcriptional feedback loops: the role of Gro/TLE1 in Hes1 oscillations.
The transcriptional repressor Hes1, a basic helix-loop-helix family protein, periodically changes its expression in the presomitic mesoderm. Its periodic pattern of expression is retained in a number of cultured murine cell lines. In this paper, we introduce an extended mathematical model for Hes1 oscillatory expression that includes regulation of Hes1 transcription by Drosophila Groucho (Gro) ...
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In both invertebrates and vertebrates, transcriptional co-repressors of the Groucho/transducin-like Enhancer of split (Gro/TLE) family regulate a number of developmental mechanisms, including neuronal differentiation. The pleiotropic activity of Gro/TLE depends on context-specific interactions with a variety of DNA-binding proteins. Most of those factors engage Gro/TLE through two different typ...
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تاریخ انتشار 2005